Cellular Shapeshifting: Mr. Sinister has the ability to control every molecule of his body, allowing him to assume the form of any one he wishes. He once reduced himself into a semi-liquid state.
Regenerative Healing Factor: Mister Sinister is able to rapidly regenerate damaged or destroyed tissue with much greater speed and efficiency than an ordinary human. Sinister can fully heal from injuries that result in massive tissue damage or loss such as multiple gunshot wounds, slashes, puncture wounds, broken bones, and severe burns within a matter of moments.
Superhuman Stamina: Mister Sinister's muscles produce considerably less fatigue toxins than the muscles of ordinary humans. He can exert himself at peak capacity several hours before fatigue begins to affect him.
Superhuman Strength possesses superhuman strength, which may be a product of his shapeshifting. Sinister is able to press lift within 2 to 10 ton range.
Superhuman Reflexes: Mister Sinister's reflexes are enhanced to levels that are beyond the human body's natural limits.
Telepathy: He can read minds and project his own thoughts into the minds of others within a radius of 250 miles (on Earth). With extreme effort he can greatly extend that radius.
Mental Paralysis: ability to induce temporary mental or physical paralysis
Mind Control: capable of controlling the minds of others but only one at a time and if the target is in his physical presence.
Dilate Power: ability to mentally paralyze a foe he's touching and the ability to psionically "turn off" the superpowers of any mutant.
Telekinesis: possesses telekinetic abilities enabling him to levitate and manipulate living beings, inanimate objects, and to some extent energy, psionically. He can “lift” as much as 10 tons of weight and possibly even more and can enable himself to “fly” at great speed.
Concussive Blasts: can fire blasts of concussive force from his hands or from the diamond-shaped scarlet mark on his forehead.
Genius-Level Geneticist: Sinister is a genius and a geneticist of the highest order, able to predict genetic mutations and splice DNA. It is quite probable his powers are the result of self-experimentation - his shapeshifitng power is due to a procedure he performed on himself with help from a time-traveling Gambit. He can also produce large amounts of clones.
Master Surgeon: He is a master surgeon.
Skilled Mechanical Engineer: having created devices that seem to have been taken from the tales of Jules Verne.
Master Manipulator: He possesses a good deal of knowledge in psychology, and is a skilled manipulator.